[2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester
• CAS No.: 161639-10-7
• Molecular Formula: C₁₆H₂₅NO₅S
• Molecular Weight: 343.444
• Mol file: 161639-10-7.mol

Synonyms:[2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

Chemical Property of [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

There total 7 articles about [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Thioacetic acid S-[2-tert-butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyl] ester (161639-08-3) → [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester (161639-10-7)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1016/0040-4039(94)88510-9

Reference yield:

5-((2-methoxy)ethoxymethoxy)-2-nitrophenylmethanol (161009-59-2) → [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester (161639-10-7)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂ / Pd/C / methanol

3: NEt₃ / tetrahydrofuran / 25 °C

4: NaI / acetone

5: 84 percent / NEt₃ / tetrahydrofuran

6: 100 percent / MeONa / methanol

With hydrogen; sodium methylate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/0040-4039(94)88510-9

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → [2-Mercaptomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester (161639-10-7)

Guidance literature:

Multi-step reaction with 5 steps

2: NEt₃ / tetrahydrofuran / 25 °C

3: NaI / acetone

4: 84 percent / NEt₃ / tetrahydrofuran

5: 100 percent / MeONa / methanol

With sodium methylate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/0040-4039(94)88510-9

upstream raw materials:

Thioacetic acid S-[2-tert-butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyl] ester

di-tert-butyl dicarbonate

[2-Hydroxymethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

[2-Iodomethyl-4-(2-methoxy-ethoxymethoxy)-phenyl]-carbamic acid tert-butyl ester

Downstream raw materials:

[4-(2-Methoxy-ethoxymethoxy)-2-(pyridin-2-yldisulfanylmethyl)-phenyl]-carbamic acid tert-butyl ester

(R)-2-Amino-3-[2-tert-butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyldisulfanyl]-propionic acid

(S)-2-Amino-4-[(R)-2-[2-tert-butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyldisulfanyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid

(R)-3-[2-tert-Butoxycarbonylamino-5-(2-methoxy-ethoxymethoxy)-benzyldisulfanyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid methyl ester