O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

Base Information

Chemical Name:O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine
CAS No.:766513-98-8
Molecular Formula:C₃₁H₃₆N₂O₈
Molecular Weight:564.635
Hs Code.:

Synonyms:O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

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Chemical Property of O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

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Technology Process of O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

There total 5 articles about O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 766513-97-7
O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine phenacyl ester

: 766513-98-8
O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

Guidance literature:: With acetic acid; zinc; In water; at 0 ℃; for 3h;
DOI:10.1021/ol0530023

Reference yield:

: 120219-32-1
L-N-(tert-butoxycarbonyl)threonine phenacyl ester

: 766513-98-8
O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / 4-(dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 20 °C

2: 60 percent / acetic acid; Zn / H₂O / 3 h / 0 °C

With dmap; acetic acid; dicyclohexyl-carbodiimide; zinc; In dichloromethane; water;
DOI:10.1021/jo070412r

Reference yield:

: 876954-04-0
N-benzyloxycarbonyl-N-methyl-3-(2-naphthyl)-L-alanine

: 766513-98-8
O-(L-N-benzyloxycarbonyl-3-(2-naphthyl)alanyl)-N-(tert-butoxycarbonyl)-L-threonine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / 4-(dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 20 °C

2: 60 percent / acetic acid; Zn / H₂O / 3 h / 0 °C

With dmap; acetic acid; dicyclohexyl-carbodiimide; zinc; In dichloromethane; water;
DOI:10.1021/jo070412r