Technology Process of (S)-((6-bromo-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalen-1-yl)ethynyl)trimethylsilane
There total 4 articles about (S)-((6-bromo-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalen-1-yl)ethynyl)trimethylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1039/c2cc35583c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid; potassium iodide; dihydrogen peroxide / methanol / 4 h
2: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / 48 h / 25 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; sulfuric acid; dihydrogen peroxide; diisopropylamine; triphenylphosphine; potassium iodide;
In
tetrahydrofuran; methanol;
2: |Sonogashira Cross-Coupling / 3: |Mitsunobu Displacement;
DOI:10.1039/c2cc35583c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / 2 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; diisopropylamine; triphenylphosphine;
In
tetrahydrofuran;
2: |Mitsunobu Displacement;
DOI:10.1039/c2cc35583c
