(R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide

Base Information

• Chemical Name: (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide
• CAS No.: 954388-96-6
• Molecular Formula: C₂₇H₃₀F₃N₅O₄S₂
• Molecular Weight: 609.694
• Mol file: 954388-96-6.mol

Synonyms:(R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide

Chemical Property of (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide

There total 5 articles about (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-4-methyl-thiazole-5-carboxylic acid (954388-95-5) → (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide (954388-96-6)

Guidance literature:

2-[(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-4-methyl-thiazole-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 3h;

With ammonia; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (954388-21-7) → (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide (954388-96-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 4 h / 20 °C

2.1: triethylamine / chloroform / 20 °C

2.2: 20 °C

3.1: acetonitrile / 0.33 h / 80 °C

4.1: trifluoroacetic acid / 1 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C

5.2: 20 °C

With hydrogenchloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; chloroform; ethyl acetate; acetonitrile;

Reference yield:

(R)-4-thiocarbamoyl-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide (954388-93-3) → (R)-4-(5-carbamoyl-4-methyl-thiazol-2-yl)-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide (954388-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetonitrile / 0.33 h / 80 °C

2.1: trifluoroacetic acid / 1 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C

3.2: 20 °C

With 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;

upstream raw materials:

2-[(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-4-methyl-thiazole-5-carboxylic acid

(R)-4-thiocarbamoyl-1-(4-trifluoromethyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-isopropyl-benzylamide

(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester

2-[(R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-4-methyl-thiazole-5-carboxylic acid tert-butyl ester