2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

Base Information

Chemical Name:2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol
CAS No.:1258234-80-8
Molecular Formula:C₂₆H₂₇N₃O₅
Molecular Weight:461.517
Hs Code.:

Synonyms:2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

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Chemical Property of 2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

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Technology Process of 2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

There total 5 articles about 2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.1%

: 1258235-05-0
(1R,4R)-1,4-bis(4-nitrophenyl)butane-1,4-diyl dimethanesulfonate

: 1258234-80-8
2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield:

: 1258226-78-6
1,4‐bis(4‐nitrophenyl)butane‐1,4‐diol

: 18755-56-1
2-(4-aminophenyl)-2-methylpropan-1-ol

: 1258234-80-8
2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

Guidance literature:: 1,4‐bis(4‐nitrophenyl)butane‐1,4‐diol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at -20 ℃; for 0.666667h; Inert atmosphere;

2-(4-aminophenyl)-2-methylpropan-1-ol; In dichloromethane; N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm401398x

Reference yield:

: 108791-66-8
1,4‐bis(4‐nitrophenyl)butane‐1,4‐dione

: 1258234-80-8
2-(4-((2S,5S)-2,5-bis(4-nitrophenyl)pyrrolidin-1-yl)phenyl)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: (S)-diphenylprolinol; Trimethyl borate; borane Ν,Ν-diethylaniline complex / tetrahydrofuran / 3.75 h / 11 - 23 °C / Inert atmosphere

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.67 h / -20 °C / Inert atmosphere

2.2: 2 h / 50 °C / Inert atmosphere

With borane Ν,Ν-diethylaniline complex; Trimethyl borate; (S)-diphenylprolinol; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm401398x