N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide

Base Information

• Chemical Name: N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide
• CAS No.: 1620992-88-2
• Molecular Formula: C₂₂H₁₈N₆OS
• Molecular Weight: 414.491

Synonyms:N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide

Chemical Property of N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide

Chemical Property:

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Technology Process of N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide

There total 4 articles about N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide (1620993-50-1) + phenyl isothiocyanate (103-72-0) → N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide (1620992-88-2)

Guidance literature:

In methanol; Reflux;

DOI:10.2174/15734064113096660044

Reference yield:

methyl 2,4-dioxo-4-(pyridin-4-yl)butanoate (374063-91-9) → N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide (1620992-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 5 h / Reflux

2: hydrazine hydrate / methanol / Reflux

3: methanol / Reflux

With hydrazine hydrate; In methanol;

DOI:10.2174/15734064113096660044

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) → N-phenyl-2-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbonyl]hydrazine-carbothioamide (1620992-88-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate; sodium / methanol; diethyl ether / 1 h / Cooling with ice

2: methanol / 5 h / Reflux

3: hydrazine hydrate / methanol / Reflux

4: methanol / Reflux

With sodium methylate; sodium; hydrazine hydrate; In methanol; diethyl ether;

DOI:10.2174/15734064113096660044

upstream raw materials:

1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide

phenyl isothiocyanate

methyl 2,4-dioxo-4-(pyridin-4-yl)butanoate

methyl (4-pyridyl) ketone

Downstream raw materials:

N-phenyl-5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-1,3,4-oxadiazol-2-amine

N-phenyl-5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-1,3,4-thiadiazol-2-amine

4-phenyl-5-(1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl)-4H-1,2,4-triazole-3-thiol

N'-(3,4-diphenylthiazol-2(3H)-ylidene)-1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide

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