6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

Base Information

Chemical Name:6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide
CAS No.:1240495-92-4
Molecular Formula:C₂₆H₂₈BFN₂O₄S
Molecular Weight:494.395
Hs Code.:

Synonyms:6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

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Chemical Property of 6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

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Technology Process of 6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

There total 4 articles about 6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240495-91-3
6-(2-bromo-5-methoxy-benzylsulfanyl)-N-(4-fluorophenyl)-nicotinamide

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1240495-92-4
6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

Guidance literature:: With triethylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere; Sealed tube;

Reference yield:

: 17624-07-6,92823-43-3
6-Mercapto-nicotinic acid

: 1240495-92-4
6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / N,N-dimethyl-formamide / 12 h

2: sodium hydroxide / ethanol / 2 h / Reflux

3: C₂H₄Cl₂N₂Pd; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; triethylamine / 1,4-dioxane / 24 h / 110 °C / Sealed tube; Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; C₂H₄Cl₂N₂Pd; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: N-(4-fluoro-phenyl)-6-mercapto-nicotinamide

: 1240495-92-4
6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 2 h / Reflux

2: C₂H₄Cl₂N₂Pd; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; triethylamine / 1,4-dioxane / 24 h / 110 °C / Sealed tube; Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; C₂H₄Cl₂N₂Pd; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol;