tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Name:tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1609932-67-3
Molecular Formula:C₃₀H₃₄N₄O₄
Molecular Weight:514.624
Hs Code.:

Synonyms:tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 9 articles about tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1609932-66-2
N-(4-(3-chloroquinoxaline-6-carbonyl)phenyl)pivalamide

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1609932-67-3
tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 60 ℃; Inert atmosphere;

Reference yield:

: 212327-10-1
7-bromo-2-methoxyquinoxaline

: 1609932-67-3
tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 12 h / 90 °C / 7500.75 Torr / Autoclave

2.1: n-butyllithium / tetrahydrofuran / -78 °C

2.2: -78 °C

3.1: manganese(IV) oxide / dichloromethane / 50 °C

4.1: hydrogenchloride / water; methanol / 0 - 20 °C

5.1: thionyl chloride / Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 60 °C / Inert atmosphere

With hydrogenchloride; triethylsilane; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3-methoxyquinoxaline-6-carbaldehyde

: 1609932-67-3
tert-butyl 4-(7-(4-pivalamidobenzoyl)quinoxalin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: manganese(IV) oxide / dichloromethane / 50 °C

3.1: hydrogenchloride / water; methanol / 0 - 20 °C

4.1: thionyl chloride / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / acetonitrile; water / 60 °C / Inert atmosphere

With hydrogenchloride; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;