4,4'-Dithiodimorpholine

Base Information

• Chemical Name: 4,4'-Dithiodimorpholine
• CAS No.: 103-34-4
• Deprecated CAS: 39393-19-6,1081512-50-6,186983-49-3
• Molecular Formula: C8H16N2O2S2
• Molecular Weight: 236.359
• Hs Code.: 2930.20
• European Community (EC) Number: 203-103-0
• NSC Number: 65239
• UNII: M786P489YF
• DSSTox Substance ID: DTXSID8026698
• Nikkaji Number: J22.138D
• Wikidata: Q27283591
• ChEMBL ID: CHEMBL582932
• Mol file: 103-34-4.mol

Synonyms:4,4'-dithiodimorpholine;N,N'-dithiodimorpholine;Sulfasan R

Chemical Property of 4,4'-Dithiodimorpholine

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 0.004Pa at 25℃
• Melting Point: 124-130 °C
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 371.7 °C at 760 mmHg
• PKA: 0.78±0.20(Predicted)
• Flash Point: 154 °C
• PSA: 75.54000
• Density: 1.33 g/cm³
• LogP: 0.73800
• Storage Temp.: Refrigerator
• Water Solubility.: 215mg/L at 20.2℃
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 236.06532010
• Heavy Atom Count: 14
• Complexity: 143

Purity/Quality:

99% ^*data from raw suppliers

4,4''-Dithiodimorpholine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Morpholines
• Canonical SMILES: C1COCCN1SSN2CCOCC2

Technology Process of 4,4'-Dithiodimorpholine

There total 6 articles about 4,4'-Dithiodimorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.85%

morpholine (110-91-8,99108-56-2) → 4,4'-dithiodimorpholine (103-34-4)

Guidance literature:

With disulfur dichloride; sodium phosphate; at 20 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield: 74.0%

morpholino dithionitrite (139558-39-7) → 4,4'-dithiodimorpholine (103-34-4)

Guidance literature:

In hexane; benzene; for 0.5h; Heating;

Reference yield: 18.0%

N,N'-thiodimorpholine (5038-11-9) → dimorpholinotrisulfide (16131-52-5) + 4,4'-dithiodimorpholine (103-34-4) + N,N'-tetrathiobismorpholine (16131-53-6)

Guidance literature:

With boron trifluoride diethyl etherate; Ambient temperature;

upstream raw materials:

morpholine

N,N'-thiodimorpholine

morpholino dithionitrite

thiocamphor

Downstream raw materials:

di-(4-tolyl)-tetrasulfide

N-Morpholino-N'-phthalimidylsulfid

morpholinosulfur trifluoride

S-benzyl morpholine-4-carbothioate

Refernces

• 1、 Okuma, Kentaro,Munakata, Kazunori,Tsubota, Toshiaki,Kanto, Masayuki,Nagahora, Noriyoshi,Shioji, Kosei,Yokomori, Yoshinobu. "Synthesis and reaction of tricyclic tetrathiins and pentathiepins: Novel formation of α-disulfines". . p. 6211 - 6217. Retrieved 2012.
• 2、 Brahemi, Ghali,Kona, Fathima R.,Fiasella, Annalisa,Buac, Daniela,Soukupová, Jitka,Brancale, Andrea,Burger, Angelika M.,Westwell, Andrew D.. "Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer". experimental part. p. 2757 - 2765. Retrieved 2010/08/20.