4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Base Information

Chemical Name:4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one
CAS No.:136006-82-1
Molecular Formula:C₁₉H₂₂Cl₂F₂O₄
Molecular Weight:423.284
Hs Code.:

Synonyms:4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

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Chemical Property of 4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

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Technology Process of 4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

There total 12 articles about 4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 136006-75-2
(4R,6S)-6-[2,4-Dichloro-6-(cyclohexylidene-fluoro-methyl)-phenoxymethyl]-4-hydroxy-tetrahydro-pyran-2-one

: 136006-82-1
4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Guidance literature:: With sodium fluoride; at 0 ℃; for 5h;
DOI:10.1021/jm00114a004

Reference yield:

: 110772-23-1
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: 136006-82-1
4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: 90 percent / NaI / acetone / 24 h / Heating

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

5: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

6: 84 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

7: 40 percent / NaF / 5 h / 0 °C

With pyridine; chromium(VI) oxide; Celite; tetrabutyl ammonium fluoride; potassium carbonate; sodium fluoride; acetic acid; hydroquinone; sodium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00114a004

Reference yield:

: Cyclohexanecarboxylic acid 2,4-dichloro-phenyl ester

: 136006-82-1
4(R)-hydroxy-6(S)-<<2,4-dichloro-6-(cyclohexyldifluoromethyl)phenoxy>methyl>tetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: AlCl₃ / 4 h / 150 °C

2: 47 percent / Et₂NSF₃ / toluene / 2 h / 25 °C

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

4: glacial acetic acid / tetrahydrofuran / 72 h / Heating

5: CrO₃, pyridine, Celite / CH₂Cl₂ / 1 h / 20 - 25 °C

6: 84 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

7: 40 percent / NaF / 5 h / 0 °C

With pyridine; chromium(VI) oxide; aluminium trichloride; diethylamino-sulfur trifluoride; Celite; tetrabutyl ammonium fluoride; potassium carbonate; sodium fluoride; acetic acid; hydroquinone; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00114a004