2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide

Base Information

• Chemical Name: 2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide
• CAS No.: 928826-43-1
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• Mol file: 928826-43-1.mol

Synonyms:2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide

Chemical Property of 2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide

There total 1 articles about 2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-5-phenyl-pent-2-enoic acid (4-dimethylamino-phenyl)-amide → 2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide (928826-43-1) + 2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide

Guidance literature:

With tert.-butylhydroperoxide; Triphenylphosphine oxide; praseodymium(III) isopropoxide; (S)‐6,6′‐diphenyl‐[1,1′‐binaphthalene]‐2,2′‐diol; In tetrahydrofuran; toluene; at 25 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1055/s-2006-956491

Reference yield: 84.0%

2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide (928826-43-1) + di-tert-butyl dicarbonate (24424-99-5) → (4-dimethylamino-phenyl)-(2-methyl-3-phenethyl-oxiranecarbonyl)-carbamic acid tert-butyl ester

Guidance literature:

With dmap; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1055/s-2006-956491

Reference yield:

2-methyl-3-phenethyl-oxirane-2-carboxylic acid (4-dimethylamino-phenyl)-amide (928826-43-1) → ((2S,3S)-2-methyl-3-phenethyloxiran-2-yl)methanol (928826-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / DMAP / acetonitrile / 12 h / 20 °C

2: 87 percent / NaBH₄ / methanol / 1.5 h / 0 - 20 °C

With dmap; sodium tetrahydroborate; In methanol; acetonitrile;

DOI:10.1055/s-2006-956491

Downstream raw materials:

((2S,3S)-2-methyl-3-phenethyloxiran-2-yl)methanol