C₁₈H₁₇NO₂

Base Information

• Chemical Name: C₁₈H₁₇NO₂
• CAS No.: 1257998-73-4
• Molecular Formula: C₁₈H₁₇NO₂
• Molecular Weight: 279.338
• Mol file: 1257998-73-4.mol

Synonyms:C₁₈H₁₇NO₂

Chemical Property of C₁₈H₁₇NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₇NO₂

There total 2 articles about C₁₈H₁₇NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-tert-butyl-4-(2-(2-nitrophenyl) ethynyl) benzene (1321627-87-5) → C18H17NO2 (1257998-73-4)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/ejoc.201000769

Reference yield:

o-nitroiodobenzene (609-73-4) + 4-tert-Butylphenylacetylene (772-38-3) → C18H17NO2 (1257998-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

2: dichloro bis(acetonitrile) palladium(II) / acetonitrile / 4 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; dichloro bis(acetonitrile) palladium(II); copper(l) iodide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile; 1: Sonogashira coupling;

DOI:10.1002/ejoc.201000769

Reference yield:

C18H17NO2 (1257998-73-4) + diethyl 2-phenylcyclopropane-1,1-dicarboxylate (3092-20-4) → diethyl 4a-(4-(tert-butyl)phenyl)-5-oxo-2-phenyl-2,3,4a,5-tetrahydro-4H-[1,2]oxazino[2,3-a]indole-4,4-dicarboxylate

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 20 ℃; for 16h; diastereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.orglett.9b02035

upstream raw materials:

1-tert-butyl-4-(2-(2-nitrophenyl) ethynyl) benzene

o-nitroiodobenzene

4-tert-Butylphenylacetylene