methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate

Base Information

• Chemical Name: methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate
• CAS No.: 957122-05-3
• Molecular Formula: C₁₅H₁₉F₂NO₃
• Molecular Weight: 299.318
• Mol file: 957122-05-3.mol

Synonyms:methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate

Chemical Property of methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate

There total 1 articles about methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(3,5-difluorophenyl)ethanone (220607-75-0) + methyl α,α-diethylglycinate hydrochloride (92398-54-4) → methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate (957122-05-3)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 - 45 ℃; for 3h;

Reference yield:

methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate (957122-05-3) + glycine ethyl ester hydrochloride (623-33-6) → methyl [(6S)-6-(3,5-difluorophenyl)-3,3-diethyl-2-oxopiperazin-1-yl]acetate + methyl [(6R)-6-(3,5-difluorophenyl)-3,3-diethyl-2-oxopiperazin-1-yl]acetate (957122-06-4)

Guidance literature:

methyl 2-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}-2-ethylbutanoate; glycine ethyl ester hydrochloride; With titanium(IV) isopropylate; acetic acid; In methanol; at 20 ℃; for 0.25h;

With sodium cyanoborohydride; In methanol; at 50 - 70 ℃; for 42h;

upstream raw materials:

2-bromo-1-(3,5-difluorophenyl)ethanone

methyl α,α-diethylglycinate hydrochloride

Downstream raw materials:

methyl [(6R)-6-(3,5-difluorophenyl)-3,3-diethyl-2-oxopiperazin-1-yl]acetate