1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline

Base Information

• Chemical Name: 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline
• CAS No.: 861959-43-5
• Molecular Formula: C₂₇H₂₁NO₂
• Molecular Weight: 391.469
• Mol file: 861959-43-5.mol

Synonyms:1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline

Chemical Property of 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline

There total 7 articles about 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-Methoxyphenylboronic acid (5720-06-9) + 3-chloro-1-(2-methoxylnaphthalen-1-yl)isoquinoline (190188-44-4) → 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline (861959-43-5)

Guidance literature:

With potassium phosphate; palladium diacetate; XPhos; In tetrahydrofuran; at 80 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1016/j.tet.2018.07.048

Reference yield:

1,3-dichloroisoquinoline (7742-73-6) → 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline (861959-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / CsF / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 18 h / 90 °C

2: 85 percent / XPhos; K₃PO₄ / Pd(OAc)2 / tetrahydrofuran / 18 h / 80 °C

With potassium phosphate; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; cesium fluoride; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki cross-coupling;

DOI:10.1016/j.tetlet.2005.04.139

Reference yield:

2-methoxynaphthalene-1-boronic acid (104116-17-8) → 1-(2-methoxynaphthalen-1-yl)-3-(2-methoxyphenyl)isoquinoline (861959-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / CsF / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 18 h / 90 °C

2: 85 percent / XPhos; K₃PO₄ / Pd(OAc)2 / tetrahydrofuran / 18 h / 80 °C

With potassium phosphate; dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; cesium fluoride; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki cross-coupling;

DOI:10.1016/j.tetlet.2005.04.139

upstream raw materials:

2-Methoxyphenylboronic acid

3-chloro-1-(2-methoxylnaphthalen-1-yl)isoquinoline

1,3-dichloroisoquinoline

2-methoxynaphthalene-1-boronic acid

Downstream raw materials:

1-[3-(2-hydroxyphenyl)isoquinolin-1-yl]naphthalen-2-ol