2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

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Chemical Name:2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide
CAS No.:676557-28-1
Molecular Formula:C₃₄H₂₁F₆N₃O₃
Molecular Weight:633.549
Hs Code.:

Synonyms:2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

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Chemical Property of 2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

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Technology Process of 2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

There total 4 articles about 2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1074-82-4
potassium phtalimide

: 676557-13-4
2-bromomethyl-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

: 676557-28-1
2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm034219a

Reference yield:

: 85422-43-1
9-phenylfuro[3,4-b]quinoline-1(3H)-one

: 676557-28-1
2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylaluminum / toluene; CH₂Cl₂ / 0.33 h / 20 °C

1.2: 73 percent / CH₂Cl₂; toluene / Heating

2.1: 87 percent / phosphorus tribromide / CH₂Cl₂ / 1 h / 20 °C

3.1: 82 percent / dimethylformamide / 2 h / 20 °C

With trimethylaluminum; phosphorus tribromide; In dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Gabriel synthesis;
DOI:10.1021/jm034219a

Reference yield:

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 676557-28-1
2-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-4-phenyl-quinoline-3-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylaluminum / toluene; CH₂Cl₂ / 0.33 h / 20 °C

1.2: 73 percent / CH₂Cl₂; toluene / Heating

2.1: 87 percent / phosphorus tribromide / CH₂Cl₂ / 1 h / 20 °C

3.1: 82 percent / dimethylformamide / 2 h / 20 °C

With trimethylaluminum; phosphorus tribromide; In dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Gabriel synthesis;
DOI:10.1021/jm034219a