(-)-N-benzoyl-α-methylphenylglycine

Base Information

• Chemical Name: (-)-N-benzoyl-α-methylphenylglycine
• CAS No.: 81838-41-7
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.3
• Mol file: 81838-41-7.mol

Synonyms:(-)-N-benzoyl-α-methylphenylglycine

Chemical Property of (-)-N-benzoyl-α-methylphenylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-N-benzoyl-α-methylphenylglycine

There total 8 articles about (-)-N-benzoyl-α-methylphenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N2.2-<(R)-N2.1-benzoyl-2-phenylalanyl>-L-phenylalanyl-L-phenylalanine dimethylamide (95525-87-4) → (-)-N-benzoyl-α-methylphenylglycine (81838-41-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 80 ℃;

DOI:10.1002/hlca.19920750522

Reference yield: 44.6%

(S)-2-Benzoylamino-2-phenyl-3-(toluene-4-sulfonyloxy)-propionic acid (185396-38-7) → (-)-N-benzoyl-α-methylphenylglycine (81838-41-7)

Guidance literature:

With sodium iodide; zinc; In N,N-dimethyl-formamide; at 120 ℃; for 10h;

Reference yield:

2,4-diphenyl-4H-oxazol-5-one (28687-81-2,719263-73-7) → (-)-N-benzoyl-α-methylphenylglycine (81838-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: (i-Pr)2EtN / dimethylformamide / 12 h / 80 °C

2: 27 percent / TsOH / acetonitrile / 48 h / Heating

3: 93 percent / 4 N aq. HCl / dioxane / 80 °C

With hydrogenchloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/hlca.19920750522

upstream raw materials:

N^2.2-<(R)-N^2.1-benzoyl-2-phenylalanyl>-L-phenylalanyl-L-phenylalanine dimethylamide

(S)-2-Benzoylamino-2-phenyl-3-(toluene-4-sulfonyloxy)-propionic acid

N-benzoyl-α-hydroxymethylphenylglycine

(-)-N-benzoyl-α-hydroxymethylphenylglycine

Downstream raw materials:

(R)-2-amino-2-phenylpropanoic acid