N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Base Information

Chemical Name:N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide
CAS No.:1393813-65-4
Molecular Formula:C₁₈H₁₆Cl₂N₄O₄S
Molecular Weight:455.321
Hs Code.:

Synonyms:N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

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Chemical Property of N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

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Technology Process of N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

There total 4 articles about N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 184779-19-9
2,4,6-trichloro-5-(2-methoxyphenoxy)pyrimidine

: benzylsulfamide potassium salt

: 1393813-65-4
N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 24h;
DOI:10.1021/jm3009103

Reference yield:

: 38768-62-6
methyl (2-methoxyphenoxy) ethanoate

: 1393813-65-4
N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C

1.2: 24 h / 20 - 32 °C

2.1: sodium methylate / methanol / 0.5 h / 0 °C

2.2: 18 h

3.1: trichlorophosphate / N,N-dimethyl-aniline / 16 h / 120 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 24 h / 20 °C

With sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103

Reference yield:

: 1878-85-9
(2-methoxyphenoxy)acetic acid

: 1393813-65-4
N-(2,6-dichloro-5-(2-methoxyphenoxy)pyrimidin-4-yl)-N'-benzylsulfamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 3 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C

2.2: 24 h / 20 - 32 °C

3.1: sodium methylate / methanol / 0.5 h / 0 °C

3.2: 18 h

4.1: trichlorophosphate / N,N-dimethyl-aniline / 16 h / 120 °C

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 24 h / 20 °C

With thionyl chloride; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103