(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

Base Information

• Chemical Name: (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one
• CAS No.: 137718-69-5
• Molecular Formula: C₂₉H₃₈N₂O₆S₂
• Molecular Weight: 574.763

Synonyms:(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

Chemical Property of (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

There total 6 articles about (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester (137718-68-4) → (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one (137718-69-5)

Guidance literature:

With tributylphosphine; carbon monoxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetic acid; at 80 ℃; for 3h;

DOI:10.1021/ja00025a035

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) → (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one (137718-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 24 h / Heating

2: 1.) NaH / 2.) DMF, 0 deg C, 12 h

3: Pd(dba)2, PBu₃, CO / acetic acid / 3 h / 80 °C

With pyridine; tributylphosphine; carbon monoxide; sodium hydride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; acetic acid;

DOI:10.1021/ja00025a035

Reference yield:

N-(allylglycinoyl)-(1R,2S)-bornane-10,2-sultam (137819-69-3) → (3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one (137718-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 24 h / Heating

2: 1.) NaH / 2.) DMF, 0 deg C, 12 h

3: Pd(dba)2, PBu₃, CO / acetic acid / 3 h / 80 °C

With pyridine; tributylphosphine; carbon monoxide; sodium hydride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; acetic acid;

DOI:10.1021/ja00025a035

upstream raw materials:

Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester

2-mesitylenesulphonyl chloride

N-(allylglycinoyl)-(1R,2S)-bornane-10,2-sultam

(2R)-N-{N-[bis(methylthio)methylidene]glycyl}bornane-10,2-sultam

Downstream raw materials:

(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methyl-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

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