Cyclophosphamide monohydrate

Base Information

• Chemical Name: Cyclophosphamide monohydrate
• CAS No.: 6055-19-2
• Molecular Formula: C7H17Cl2N2O3P
• Molecular Weight: 279.13
• Hs Code.: 29349990
• European Community (EC) Number: 629-456-4,640-398-9
• UN Number: 2811
• UNII: 8N3DW7272P
• DSSTox Substance ID: DTXSID6024888
• Wikidata: Q27106287
• NCI Thesaurus Code: C405
• RXCUI: 3002
• ChEMBL ID: CHEMBL1200796
• Mol file: 6055-19-2.mol

Synonyms:(+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate;B 518;B-518;B518;Cyclophosphamide;Cyclophosphamide Anhydrous;Cyclophosphamide Monohydrate;Cyclophosphamide, (R)-Isomer;Cyclophosphamide, (S)-Isomer;Cyclophosphane;Cytophosphan;Cytophosphane;Cytoxan;Endoxan;Neosar;NSC 26271;NSC-26271;NSC26271;Procytox;Sendoxan

Chemical Property of Cyclophosphamide monohydrate

Chemical Property:

• Appearance/Colour: White to Off-White Solid
• Vapor Pressure: 5.72E-08mmHg at 25°C
• Melting Point: 49-51 °C(lit.)
• Boiling Point: 336.1 °C at 760 mmHg
• Flash Point: 157.1 °C
• PSA: 60.61000
• LogP: 2.14850
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• Water Solubility.: 40 g/L
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 278.0353848
• Heavy Atom Count: 15
• Complexity: 212
• Transport DOT Label: Poison

Purity/Quality:

99% ^*data from raw suppliers

Cyclophosphamide monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 45-25-61-46-36/37/38-23/24/25
• Safety Statements: 53-45-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Other Organic Compounds
• Canonical SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl.O
• Recent ClinicalTrials: Evaluation of the Safety and Efficacy of Nipent, Cytoxan, and Rituxan
• Recent EU Clinical Trials: Phase 2b Single Arm Study of Maveropepimut-S and Low-Dose Cyclophosphamide in Subjects with Platinum-Resistant, Epithelial Ovarian
• Uses: It is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen. antineoplastic, alkylating agent alkylating agent in cancer therapy An immunosuppressive, cytotoxic apoptosis inducer. Cyclophosphamide monohydrate is used to treat cancers, autoimmune disorders and AL amyloidosis. It is a nitrogen mustard alkylating agent and reacts with deoxyribonucleic acid (DNA) to get its alkylated derivative. It is also involved in cancer research as a tool that induces apoptosis in tumor cells.