7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

Base Information

Chemical Name:7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester
CAS No.:1407159-68-5
Molecular Formula:C₂₃H₂₈N₄O₅
Molecular Weight:440.499
Hs Code.:

Synonyms:7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

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Chemical Property of 7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

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Technology Process of 7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

There total 6 articles about 7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1197892-23-1
7-(4-hydroxyphenylcarbamoyl)heptananoic acid methyl ester

: 1407159-67-4
toluene-4-sulfonic acid 3-azido-5-methoxybenzyl ester

: 1407159-68-5
7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

Guidance literature:: With potassium carbonate; In acetone; for 12h; Reflux;
DOI:10.1016/j.bmcl.2012.08.104

Reference yield:

: 3946-32-5
suberic acid monomethyl ester

: 1407159-68-5
7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: palladium 10% on activated carbon; methanol / 20 °C

3: potassium carbonate / acetone / 12 h / Reflux

With methanol; palladium 10% on activated carbon; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;
DOI:10.1016/j.bmcl.2012.08.104

Reference yield:

: 1261566-52-2
(3-amino-5-methoxyphenyl)methanol

: 1407159-68-5
7-[4-(3-azido-5-methoxybenzyloxy)phenylcarbamoyl]heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite; sodium azide / water / 5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

3: potassium carbonate / acetone / 12 h / Reflux

With sodium azide; potassium carbonate; triethylamine; sodium nitrite; In dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2012.08.104