3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

Base Information

Chemical Name:3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene
CAS No.:606123-12-0
Molecular Formula:C₁₉H₂₂F₂O₂S
Molecular Weight:352.445
Hs Code.:

Synonyms:3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

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Chemical Property of 3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

Chemical Property:

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Technology Process of 3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

There total 3 articles about 3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 4347-31-3
2-formylthiophene-3-boronic acid

: 606123-10-8
1-tert-butyl-2-(2,2-difluoro-ethoxy)-5-ethyl-3-iodo-benzene

: 606123-12-0
3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; Heating;
DOI:10.1021/jm020401k

Reference yield:

: 96-70-8
6-di-t-butyl-4-ethylphenol

: 606123-12-0
3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / N-iodosuccinimide; p-toluenesulfonic acid / CH₂Cl₂ / 20 °C

2: 97 percent / Cs₂CO₃ / dimethylformamide / 20 °C

3: 97 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Suzuki coupling;
DOI:10.1021/jm020401k

Reference yield:

: 330935-93-8
2-tert-butyl-4-ethyl-6-iodophenol

: 606123-12-0
3-[5-ethyl-3-tert-butyl-2-(2,2-difluoroethoxy)benzene]-2-formylthiophene

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Cs₂CO₃ / dimethylformamide / 20 °C

2: 97 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; In ethanol; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1021/jm020401k