Azane;cyclohexanamine;platinum(4+);diacetate;dichloride

Base Information

• Chemical Name: Azane;cyclohexanamine;platinum(4+);diacetate;dichloride
• CAS No.: 129580-63-8
• Molecular Formula: C₁₀H₂₂Cl₂N₂O₄Pt
• Molecular Weight: 500.282
• Mol file: 129580-63-8.mol

Synonyms:azane;cyclohexanamine;platinum(4+);diacetate;dichloride;AKOS015833635;DB04996;F85029

Chemical Property of Azane;cyclohexanamine;platinum(4+);diacetate;dichloride

Chemical Property:

• Vapor Pressure: 8.07mmHg at 25°C
• Boiling Point: 134.5 °C at 760 mmHg
• Flash Point: 32.2 °C
• PSA: 81.86000
• LogP: 3.70610
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 499.060457
• Heavy Atom Count: 19
• Complexity: 71.7

Purity/Quality:

99% ^*data from raw suppliers

Satraplatin >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)[O-].CC(=O)[O-].C1CCC(CC1)N.N.[Cl-].[Cl-].[Pt+4]
• Uses: Antineoplastic.
• Clinical Use: This newest organometallic agent currently is in clinical trials as a second-line agent for the treatment of hormone-refractory prostate cancer . There is hope that it also will find value in ovarian cancer and small cell lung cancer.

Technology Process of Azane;cyclohexanamine;platinum(4+);diacetate;dichloride

There total 3 articles about Azane;cyclohexanamine;platinum(4+);diacetate;dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (124721-03-5,1313200-52-0,146924-11-0) + acetic anhydride (108-24-7) → (OC6-6-22)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV) (129580-63-8,146924-14-3,146924-15-4,152375-90-1,177470-23-4,177470-24-5,281654-38-4)

Guidance literature:

In acetic anhydride; Irradiation (UV/VIS); stirring at room temp. for 5 d in daylight; collection (filtration), washing (Et2O); elem. anal.;

DOI:10.1021/ic951548n

Reference yield: 67.0%

trans,cis,cis-Pt(NH3)(cyclohexylamine)Cl2(OH)2 (124721-03-5,1313200-52-0,146924-11-0) + acetic anhydride (108-24-7) → (OC6-6-22)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV) (129580-63-8,146924-14-3,146924-15-4,152375-90-1,177470-23-4,177470-24-5,281654-38-4)

Guidance literature:

In acetic anhydride; stirring for 8 d; collection (filtration), washing (Et2O), drying in air; elem. anal.;

DOI:10.1021/ic960983u

Reference yield: 62.0%

trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (124721-03-5,1313200-52-0,146924-11-0) + acetic anhydride (108-24-7) → (OC6-6-12)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV) (129580-63-8,146924-14-3,146924-15-4,152375-90-1,177470-23-4,177470-24-5,281654-38-4)

Guidance literature:

In diethyl ether; acetic anhydride; stirring in Ac2O/Et2O=5:3 v/v in dark for 3 d; collection (filtration), washing (Et2O); elem. anal.;

DOI:10.1021/ic951548n

upstream raw materials:

trans,trans,trans-[PtCl₂(OH)2(c-C₆H₁₁NH₂)(NH₃)]

acetic anhydride

trans,cis,cis-Pt(NH₃)(cyclohexylamine)Cl₂(OH)2

Downstream raw materials:

trans-Pt(acetate)2(cyclohexylamine)NH₃

cis-Pt(acetate)2(cyclohexylamine)NH₃

trans-[PtCl₂(NH₃)(cyclohexylamine)]

Refernces

• 1、 Barnard, Christopher F. J.,Vollano, Jean F.,Chaloner, Penny A.,Dewa, Shaliza Z.. "Studies on the oral anticancer drug JM-216: Synthesis and characterization of isomers and related complexes". . p. 3280 - 3284. Retrieved 2008/10/09.