N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

Base Information

Chemical Name:N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide
CAS No.:1067191-55-2
Molecular Formula:C₂₄H₂₃N₃O₃
Molecular Weight:401.465
Hs Code.:

Synonyms:N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

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Chemical Property of N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

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Technology Process of N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

There total 4 articles about N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1067192-91-9
N-[4-(cyano-dimethyl-methyl)-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3,4-dimethoxy-benzamide

: 19524-06-2
4-bromopyridine hydrochloride

: 1067191-55-2
N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

Guidance literature:: N-[4-(cyano-dimethyl-methyl)-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3,4-dimethoxy-benzamide; 4-bromopyridine hydrochloride; With potassium carbonate; In 1,2-dimethoxyethane; water; for 0.5h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 100 ℃; for 8h; Microwave irradiation;

Reference yield:

: 1067192-69-1
2-(4-amino-2-bromo-phenyl)-2-methyl-propionitrile

: 1067191-55-2
N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 1 h / 100 °C / Microwave irradiation

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1.5 h / 95 °C

3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.5 h

3.2: 8 h / 100 °C / Microwave irradiation

With pyridine; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; dimethyl sulfoxide;

Reference yield:

: 1067190-79-7
N-[3-bromo-4-(cyano-dimethyl-methyl)-phenyl]-3,4-dimethoxy-benzamide

: 1067191-55-2
N-[4-(cyano-dimethyl-methyl)-3-pyridin-4-yl-phenyl]-3,4-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 1.5 h / 95 °C

2.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.5 h

2.2: 8 h / 100 °C / Microwave irradiation

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; dimethyl sulfoxide;