N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester

Base Information

• Chemical Name: N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester
• CAS No.: 797761-61-6
• Molecular Formula: C₄₁H₂₈F₁₅N₃O₁₀
• Molecular Weight: 1007.66

Synonyms:N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester

Chemical Property of N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester

There total 4 articles about N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

pentafluorophenyl trifloroacetate (14533-84-7) + Nα-(3-carboxy-1-oxopropyl)-Nε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid (797761-60-5) → Nα-(3-carboxy-1-oxopropyl)-Nε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester (797761-61-6)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/ja046426l

Reference yield:

N6-[(benzyloxy)carbonyl]-L-lysine (1155-64-2,57705-97-2,67178-46-5,25931-47-9) → Nα-(3-carboxy-1-oxopropyl)-Nε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester (797761-61-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 98 percent / Et₃N / dimethylformamide / 8 h / 20 °C

2.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / dimethylformamide / 0.5 h / 0 °C

2.2: 86 percent / dimethylformamide / 15 h / 20 °C

3.1: 74 percent / (Ph₃P)4Pd; N-methylaniline / tetrahydrofuran / 14 h

4.1: 79 percent / pyridine / dimethylformamide / 1 h / 20 °C

With pyridine; 1-hydroxy-pyrrolidine-2,5-dione; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; dicyclohexyl-carbodiimide; N-methylaniline; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja046426l

Reference yield:

Nα-(3-carboxy-1-oxopropyl)-Nε-(benzyloxycarbonyl)-L-lysine allyl ester (797761-58-1) → Nα-(3-carboxy-1-oxopropyl)-Nε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester (797761-61-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-hydroxysuccinimide; dicyclohexylcarbodiimide / dimethylformamide / 0.5 h / 0 °C

1.2: 86 percent / dimethylformamide / 15 h / 20 °C

2.1: 74 percent / (Ph₃P)4Pd; N-methylaniline / tetrahydrofuran / 14 h

3.1: 79 percent / pyridine / dimethylformamide / 1 h / 20 °C

With pyridine; 1-hydroxy-pyrrolidine-2,5-dione; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dicyclohexyl-carbodiimide; N-methylaniline; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja046426l

upstream raw materials:

pentafluorophenyl trifloroacetate

N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid

N₆-[(benzyloxy)carbonyl]-L-lysine

N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysine allyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 797761-61-6 N^α-(3-carboxy-1-oxopropyl)-N^ε-(benzyloxycarbonyl)-L-lysyl-L-glutamic acid tris(pentafluorophenyl)ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send