(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

Base Information

Chemical Name:(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol
CAS No.:123169-13-1
Molecular Formula:C₁₂H₁₄FN₃O₆
Molecular Weight:315.258
Hs Code.:

Synonyms:(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

Suppliers and Price of (+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

Chemical Property:

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Technology Process of (+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

There total 1 articles about (+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 110864-90-9
(+/-)-(6aα,8β,9β,9aβ)-8-<(2,4-dinitrophenyl)amino>-9-fluorohexahydro-2,2,4,4-tetrakis(1-methylethyl)cyclopenta-1,3,5,2,4-trioxadisilocin

: 123169-13-1
(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;
DOI:10.1021/jm00163a030

Reference yield:

: 123169-13-1
(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 110864-93-2
(+/-)-1-<(1α,2α,3β,4α)-2-fluoro-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-iodo-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Dowex 2(OH^-) resin, 2.) 1N HCl / 1.) acetone, water, RT, 24 h

2: DBU, 4A sieves / dimethylformamide; benzene / a.) -15 deg C, 1 h, b.) RT, 18 h

3: 5percent H₂SO₄ / 3 h / Heating

4: 21 percent / I₂, 1N HNO₃ / CHCl₃ / 1.) reflux, 4 h, 2.) 5 deg C, 16 h

With hydrogenchloride; 4 A molecular sieve; Dowex 2(OH^-) resin; sulfuric acid; iodine; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00163a030

Reference yield:

: 123169-13-1
(+/-)-(1α,2β,3α,4α)-4-<(2,4-dinitrophenyl)amino>-3-fluoro-2-hydroxycyclopentanemethanol

: 110312-76-0
(+/-)-(1α,2β,3α,4α)-4-amino-3-fluoro-2-hydroxycyclopentanemethanol hydrochloride salt

Guidance literature:: With hydrogenchloride; Dowex 2(OH^-) resin; Yield given. Multistep reaction; 1.) acetone, water, RT, 24 h;
DOI:10.1021/jm00163a030