o-anisylphosphonic dichloride

Base Information

• Chemical Name: o-anisylphosphonic dichloride
• CAS No.: 53839-05-7
• Molecular Formula: C₇H₇Cl₂O₂P
• Molecular Weight: 225.011
• Mol file: 53839-05-7.mol

Synonyms:o-anisylphosphonic dichloride

Chemical Property of o-anisylphosphonic dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-anisylphosphonic dichloride

There total 5 articles about o-anisylphosphonic dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl [2-(methoxy)phenyl]phosphonate (15286-17-6) → o-anisylphosphonic dichloride (53839-05-7)

Guidance literature:

With phosphorus pentachloride; Heating;

Reference yield:

(2-hydroxy-phenyl)-phosphonic acid diethyl ester (69646-14-6) → o-anisylphosphonic dichloride (53839-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 10 h / 90 °C / Inert atmosphere

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.8b02982

Reference yield:

O,O-diethyl O-phenyl phosphate (2510-86-3) → o-anisylphosphonic dichloride (53839-05-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 6 h / -78 - 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / 10 h / 90 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; potassium carbonate; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.8b02982

upstream raw materials:

diethyl [2-(methoxy)phenyl]phosphonate

2-bromoanisole

O,O-diethyl O-phenyl phosphate

(2-hydroxy-phenyl)-phosphonic acid diethyl ester