2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione

Base Information

• Chemical Name: 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione
• CAS No.: 1438435-22-3
• Molecular Formula: C₁₈H₂₈O₄
• Molecular Weight: 308.418
• Mol file: 1438435-22-3.mol

Synonyms:2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione

Chemical Property of 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione

There total 4 articles about 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione (1438435-21-2) + allyl bromide (106-95-6) → 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione (1438435-22-3)

Guidance literature:

2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201200499

Reference yield:

C10H16O3 (1438435-20-1) → 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione (1438435-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 40 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201200499

Reference yield:

1,3-cylohexanedione (504-02-9) → 2-allyl-2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione (1438435-22-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-benzyl-trimethylammonium hydroxide / water / 16 h / 35 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 20 °C

3.1: pyridinium p-toluenesulfonate / dichloromethane / 40 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; pyridinium p-toluenesulfonate; N-benzyl-trimethylammonium hydroxide; sodium hydride; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201200499

upstream raw materials:

C₁₀H₁₆O₃

2-[4-(2-tetrahydropyranyloxy)butyl]-1,3-cyclohexanedione

allyl bromide

1,3-cylohexanedione

Downstream raw materials:

2-allyl-2-(4-hydroxybutyl)cyclohexane-1,3-dione

2-allyl-2-(3-formylpropyl)-1,3-cyclohexanedione