1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

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Chemical Name:1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide
CAS No.:1449320-30-2
Molecular Formula:C₃₇H₃₆N₆O₅S
Molecular Weight:676.796
Hs Code.:

Synonyms:1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

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Chemical Property of 1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

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Technology Process of 1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

There total 6 articles about 1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.1%

: 1449320-32-4
1-benzyl-1H-pyrazol-4-carboxylic acid [5-(3-hydroxyphenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

: 3647-69-6
4-(2-chloroethyl)morpholine hydrochride

: 1449320-30-2
1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

Reference yield:

: 1449318-35-7
1-benzyl-1H-pyrazol-4-carboxylic acid (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

: 1449320-30-2
1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 4 h / 20 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 1 h / 120 °C / Microwave irradiation

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; caesium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1449319-84-9
1-benzyl-1H-pyrazol-4-carboxylic acid [5-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

: 1449320-30-2
1-benzyl-1H-pyrazol-4-carboxylic acid [5-[3-(2-morpholin-4-ylethoxy)phenyl]-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 1 h / 120 °C / Microwave irradiation

2: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; caesium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;