N₄-(2-chlorophenyl)-N₂-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride

Base Information

• Chemical Name: N₄-(2-chlorophenyl)-N₂-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride
• CAS No.: 1395886-29-9
• Molecular Formula: C₁₇H₁₂ClFN₈*ClH
• Molecular Weight: 419.248

Synonyms:N₄-(2-chlorophenyl)-N₂-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride

Chemical Property of N₄-(2-chlorophenyl)-N₂-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride

Chemical Property:

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Technology Process of N₄-(2-chlorophenyl)-N₂-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride

There total 4 articles about N₄-(2-chlorophenyl)-N₂-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

4-(1H-tetrazol-5-yl)aniline (46047-18-1) + N4-(2-chlorophenyl)-2-chloro-5-fluoropyrimidine-4-amine (1395918-39-4) → N4-(2-chlorophenyl)-N2-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride (1395886-29-9)

Guidance literature:

In ethanol; at 170 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

5-(4-nitrophenyl)-1H-1,2,3,4-tetrazole (16687-60-8) → N4-(2-chlorophenyl)-N2-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride (1395886-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: ethanol / 0.67 h / 170 °C / Microwave irradiation

With hydrogen; palladium 10% on activated carbon; In methanol; ethanol;

Reference yield:

4-nitrobenzonitrile (619-72-7) → N4-(2-chlorophenyl)-N2-[4-(2H-tetrazol-5-yl)phenyl]-5-fluoropyrimidine-2,4-diamine hydrochloride (1395886-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide; triethylamine hydrochloride / toluene / 100 °C

2: hydrogen / palladium 10% on activated carbon / methanol

3: ethanol / 0.67 h / 170 °C / Microwave irradiation

With sodium azide; hydrogen; triethylamine hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; toluene;

upstream raw materials:

4-nitrobenzonitrile

4-(1H-tetrazol-5-yl)aniline

N⁴-(2-chlorophenyl)-2-chloro-5-fluoropyrimidine-4-amine

5-(4-nitrophenyl)-1H-1,2,3,4-tetrazole

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