(S)-(+)-4-Phenyl-2-oxazolidinone

Base Information Edit

Chemical Name:(S)-(+)-4-Phenyl-2-oxazolidinone
CAS No.:99395-88-7
Molecular Formula:C9H9NO2
Molecular Weight:163.176
Hs Code.:29349990
European Community (EC) Number:619-429-5
UNII:DJ3K4V6J29
DSSTox Substance ID:DTXSID10912726
Nikkaji Number:J616.889B
Wikidata:Q72498037
Mol file:99395-88-7.mol

Synonyms:99395-88-7;(S)-(+)-4-Phenyl-2-oxazolidinone;(s)-4-phenyl-2-oxazolidinone;(S)-4-Phenyloxazolidin-2-one;(4S)-4-phenyl-1,3-oxazolidin-2-one;2-Oxazolidinone, 4-phenyl-, (4S)-;(4S)-4-phenyloxazolidin-2-one;86217-38-1;(S)-Poz;DJ3K4V6J29;(+)-4-phenyl-2-oxazolidinone;(4S)-4-phenyl-2-oxazolidinone;2-Oxazolidinone, 4-phenyl-, (S)-;MFCD00043396;(S)-4-phenyloxazolidinone;SCHEMBL4562;UNII-DJ3K4V6J29;4beta-Phenyloxazolidine-2-one;(S)-4-phenyloxazoldin-2-one;(S)-4-Phenyl-oxazolidin-2-on;(S)-4-phenyl-oxazolidin-2-one;DTXSID10912726;4-Phenyl-2-oxazolidinone, (4S)-;(s)-(+)-4-phenyloxazolidin-2-one;AKOS005259882;(S)-(+)-4-phenyl-oxazolidin-2-one;AC-8429;CS-M-57852;AS-12030;4-Phenyl-4,5-dihydro-1,3-oxazol-2-ol;(S)-(+)-4-Phenyl-2-oxazolidinone, 98%;AM20060772;CS-0031471;P1308;(4s)-(+)-4-phenyl-1,3-oxazolidin-2-one;EN300-258709;A846016

Suppliers and Price of (S)-(+)-4-Phenyl-2-oxazolidinone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-4-Phenyl-2-oxazolidinone
100g
$ 675.00

TRC
(S)-4-Phenyl-2-oxazolidinone
5g
$ 110.00

TCI Chemical
(S)-(+)-4-Phenyl-2-oxazolidinone >99.0%(GC)
25g
$ 18.00

TCI Chemical
(S)-(+)-4-Phenyl-2-oxazolidinone >99.0%(GC)
5g
$ 12.00

SynQuest Laboratories
(S)-(+)-4-Phenyl-2-oxazolidinone 98%
25 g
$ 32.00

SynQuest Laboratories
(S)-(+)-4-Phenyl-2-oxazolidinone 98%
100 g
$ 117.00

SynQuest Laboratories
(S)-(+)-4-Phenyl-2-oxazolidinone 98%
500 g
$ 439.00

Sigma-Aldrich
(S)-(+)-4-Phenyl-2-oxazolidinone 98%
5g
$ 345.00

Sigma-Aldrich
(S)-(+)-4-Phenyl-2-oxazolidinone 98%
1g
$ 128.00

Oakwood
(S)-(+)-4-Phenyl-2-oxazolidinone
500g
$ 175.00

Total 178 raw suppliers

Chemical Property of (S)-(+)-4-Phenyl-2-oxazolidinone Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:7.79E-07mmHg at 25°C
Melting Point:129-132 °C(lit.)
Refractive Index:72 ° (C=1, AcOEt)
Boiling Point:407 °C at 760 mmHg
PKA:12.05±0.40(Predicted)
Flash Point:200 °C
PSA：38.33000
Density:1.195 g/cm³
LogP:1.79630
Storage Temp.:Store at 0-5°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:163.063328530
Heavy Atom Count:12
Complexity:175

Purity/Quality:

99% ^*data from raw suppliers

(S)-4-Phenyl-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,F+
Hazard Codes:Xi,F+
Statements: 12-36
Safety Statements: 24/25-33-26-16-7/9

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(NC(=O)O1)C2=CC=CC=C2
Isomeric SMILES:C1[C@@H](NC(=O)O1)C2=CC=CC=C2
Uses S)-4-Phenyl-2-oxazolidinone is an intermediate for the synthesis and development for cholesterol absorption inhibitor AZD4121. Ezetimibe intermediate Versatile chiral auxiliary for asymmetric synthesis which is easily recycled under mild conditions, thus enhancing its commercial potential. For a recent review, see Aldrichimica Acta .

Technology Process of (S)-(+)-4-Phenyl-2-oxazolidinone

There total 95 articles about (S)-(+)-4-Phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 34375-80-9
4-phenyl-4-oxazoline-2-one

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

Guidance literature:: With (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; hydrogen; nickel diacetate; In 2,2,2-trifluoroethanol; at 50 ℃; for 12h; under 760.051 Torr; Solvent; Temperature; Pressure; Reagent/catalyst; enantioselective reaction; Catalytic behavior;
DOI:10.1021/acscatal.0c02569

Reference yield: 96.0%

: 148766-15-8
(R,E)-3-but-2-enoyl-4-phenyloxazolidin-2-one

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

: 132435-54-2
(2S,3S)-3-methylpyroglutamic acid

: 261768-47-2
o-[N-(α-picolyl)amino]acetophenone

Guidance literature:: (R,E)-3-but-2-enoyl-4-phenyloxazolidin-2-one; Schiff base of glycine with o-[N-α-pycolylamino]acetophenone; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

With hydrogenchloride; In methanol; at 70 ℃;

With cation-exchange resin Dowex; water;
DOI:10.1021/ol990402f

Reference yield: 95.0%

: 124-38-9,18923-20-1
carbon dioxide

: 20989-17-7
(2S)-2-phenylglycinol

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

Guidance literature:: carbon dioxide; (2S)-2-phenylglycinol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.75h;

With tributylphosphine; di-tert-butyl-diazodicarboxylate; In acetonitrile; at 0 ℃; for 0.333333h;
DOI:10.1021/ol0491080