6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester

Base Information

• Chemical Name: 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester
• CAS No.: 702698-98-4
• Molecular Formula: C₁₆H₁₄N₄O₄
• Molecular Weight: 326.312
• Mol file: 702698-98-4.mol

Synonyms:6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester

Chemical Property of 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester

There total 1 articles about 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

ethyl 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-4H-pyran-3-carboxylate (72568-54-8) → 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester (702698-98-4)

Guidance literature:

With ammonium acetate; acetic acid; at 116 ℃;

DOI:10.1016/j.bmc.2004.02.017

Reference yield: 86.0%

cycloheptanone (502-42-1) + 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester (702698-98-4) → 5-amino-2-methyl-4-(3-nitro-phenyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b][1,8]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; Heating;

DOI:10.1016/j.bmc.2004.02.017

Reference yield: 54.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid ethyl ester (702698-98-4) → 5-amino-2-methyl-4-(3-nitro-phenyl)-6,7,8,9-tetrahydro-benzo[b][1,8]naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; Heating;

DOI:10.1016/j.bmc.2004.02.017

upstream raw materials:

ethyl 6-amino-5-cyano-2-methyl-4-(3-nitrophenyl)-4H-pyran-3-carboxylate