methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

Base Information

Chemical Name:methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate
CAS No.:74615-10-4
Molecular Formula:C₃₉H₃₅N₃O₉S
Molecular Weight:721.788
Hs Code.:

methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

Synonyms:methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

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Chemical Property of methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

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Technology Process of methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

There total 23 articles about methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74615-09-1
methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<3-methoxy-6-nitro-2-<(phenylsulfonyl)oxy>phenyl>-1-oxo-2-propenyl>-3-methyl-2-pyridinecarboxylate

: 74615-10-4
methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

Guidance literature:: With sodium disulfite; In methanol; water; for 2h; Heating;
DOI:10.1021/ja00531a054

Reference yield:

: 74615-06-8
methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-formyl-3-methyl-2-pyridinecarboxylate

: 74615-10-4
methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium, HMPA / 1.) THF, -78 - -75 deg C, 2.) THF, -75 -> 15 deg C, 40 min

2: activated manganese dioxide / CHCl₃ / 1 h

3: 1.) KH / 1.) benzene, room temperature, 15 min, 2.) benzene, room temperature, 75 min

4: 60 percent / aq. sodium hydrosulfite / methanol / 3 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; sodium disulfite; n-butyllithium; potassium hydride; In methanol; chloroform;
DOI:10.1021/ja00366a028

Reference yield:

: 74615-01-3
methyl 4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-5-formyl-3,6-dimethyl-2-pyridinecarboxylate

: 74615-10-4
methyl 5-amino-4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-<3-<6-methoxy-5-<(phenylsulfonyl)oxy>phenyl>-2-quinolyl>-3-methyl-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: pertrifluoroacetic acid, Na₂HPO₄ / CH₂Cl₂

2: 10 percent / aq. KMnO₄ / acetone / 3 h

3: 1.) triethylamine, diphenylphosphoryl azide, 2.) water / 1.) benzene, reflux, 1 h, 2.) reflux, 30 min

4: 1.) acetic anhydride, 2.) methanolic K₂CO₃ / 1.) 120 - 125 deg C, 2 h, 2.) room temperature, 21 h

5: 88 percent / activated manganese oxide / CHCl₃ / 2 h

6: 1.) n-butyllithium, HMPA / 1.) THF, -78 - -75 deg C, 2.) THF, -75 -> 15 deg C, 40 min

7: activated manganese dioxide / CHCl₃ / 1 h

8: 1.) KH / 1.) benzene, room temperature, 15 min, 2.) benzene, room temperature, 75 min

9: 60 percent / aq. sodium hydrosulfite / methanol / 3 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; manganese oxide; manganese(IV) oxide; potassium permanganate; sodium disulfite; disodium hydrogenphosphate; n-butyllithium; diphenylphosphoranyl azide; water; acetic anhydride; potassium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; chloroform; acetone;
DOI:10.1021/ja00366a028