5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide

Base Information

• Chemical Name: 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide
• CAS No.: 1151811-09-4
• Molecular Formula: C₂₃H₃₃NO₃Si
• Molecular Weight: 399.605
• Mol file: 1151811-09-4.mol

Synonyms:5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide

Chemical Property of 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide

There total 1 articles about 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butylchlorodiphenylsilane (58479-61-1) + 5-hydroxy-pentanoic acid methyl-methoxy-amide (187756-41-8) → 5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide (1151811-09-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b821431j

Reference yield: 99.6%

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide (1151811-09-4) + 1-propynylmagnesium bromide (16466-97-0,13254-27-8) → 8-(tert-butyl-diphenyl-silanyloxy)-oct-2-yn-4-one (1152234-65-5)

Guidance literature:

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide; 1-propynylmagnesium bromide; In tetrahydrofuran; at -30 - 20 ℃; for 7.5h; Inert atmosphere;

With water; rochelle salt; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.tet.2008.10.074

Reference yield: 80.0%

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide (1151811-09-4) + 6-Bromo-1-hexene (2695-47-8) → 1-(tert-butyldiphenylsilyloxy)undec-10-en-5-one (1151811-11-8)

Guidance literature:

6-Bromo-1-hexene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; Inert atmosphere;

5-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid methyl-methoxy-amide; In tetrahydrofuran; pentane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/b821431j

upstream raw materials:

tert-butylchlorodiphenylsilane

5-hydroxy-pentanoic acid methyl-methoxy-amide

Downstream raw materials:

7-(tert-butyldiphenylsilyloxy)heptan-3-one

8-(tert-butyl-diphenyl-silanyloxy)-oct-2-yn-4-one

1-(tert-butyldiphenylsilyloxy)undec-10-en-5-one