2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

Base Information

Chemical Name:2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone
CAS No.:887142-53-2
Molecular Formula:C₄₆H₆₉NO₅Si
Molecular Weight:744.143
Hs Code.:

2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

Synonyms:2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

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Chemical Property of 2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

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Technology Process of 2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

There total 1 articles about 2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: ((S)-1,1,3,3,6-Pentamethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-7-yl)-trimethylsilanyl-amine

: 887142-46-3
(3aR,5aR,6R,7S,9aS,9bS)-6-Benzyloxymethyl-6,9a,9b-trimethyl-7-triethylsilanyloxy-decahydro-naphtho[1,2-c]furan-1-one

: 887142-53-2
2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

Guidance literature:: ((S)-1,1,3,3,6-Pentamethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-7-yl)-trimethylsilanyl-amine; With sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -40 - 0 ℃;

(3aR,5aR,6R,7S,9aS,9bS)-6-Benzyloxymethyl-6,9a,9b-trimethyl-7-triethylsilanyloxy-decahydro-naphtho[1,2-c]furan-1-one; In diethyl ether; hexane; cyclohexane; at -65 - 0 ℃; for 0.666667h;
DOI:10.1021/ol0602912

Reference yield: 98.0%

: 887142-53-2
2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

: 887142-44-1
[(1S,2R,4aR,5R,6S,8aS)-5-Benzyloxymethyl-1,5,8a-trimethyl-1-((S)-6,6,8,8-tetramethyl-6,8,8a,9-tetrahydro-1H-7-oxa-1-aza-cyclopenta[b]fluoren-2-yl)-6-triethylsilanyloxy-decahydro-naphthalen-2-yl]-methanol

Guidance literature:: With 2,2,2-trifluoroethanol; for 6h; Heating;
DOI:10.1021/ol0602912

Reference yield:

: 887142-53-2
2-((S)-7-Amino-1,1,3,3-tetramethyl-1,3,9,9a-tetrahydro-2-oxa-fluoren-6-yl)-1-((1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-2-hydroxymethyl-1,5,8a-trimethyl-6-triethylsilanyloxy-decahydro-naphthalen-1-yl)-ethanone

: Methanesulfonic acid (1S,2R,4aR,5R,6S,8aS)-5-benzyloxymethyl-1,5,8a-trimethyl-1-((S)-6,6,8,8-tetramethyl-6,8,8a,9-tetrahydro-1H-7-oxa-1-aza-cyclopenta[b]fluoren-2-yl)-6-triethylsilanyloxy-decahydro-naphthalen-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 2,2,2-trifluoro-ethanol / 3 h / Heating

2: 93 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0.42 h / 0 °C

With dmap; In dichloromethane; 2,2,2-trifluoroethanol;
DOI:10.1021/jo062422i