N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Base Information

Chemical Name:N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide
CAS No.:1256488-40-0
Molecular Formula:C₂₆H₂₅FN₂O₆S
Molecular Weight:512.559
Hs Code.:

Synonyms:N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

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Technology Process of N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

There total 5 articles about N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256489-00-5
C₂₇H₂₈FN₃O₅S

: 1256488-40-0
N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Guidance literature:: C₂₇H₂₈FN₃O₅S; With hydrogen bromide; In acetic acid; at 65 ℃;

With sodium hydrogencarbonate; In water; acetic acid;

Reference yield:

: 1206776-41-1
4-bromo-2-tert-butyl-6-iodophenol

: 1256488-40-0
N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 70 °C

2: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / ethanol / 2 h / Reflux

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 90 °C / Sealed tube; Microwave Irradiation

4: hydrogen bromide / acetic acid / 65 °C

With copper(l) iodide; hydrogen bromide; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1206776-45-5
C₂₁H₂₃BrN₂O₄S

: 1256488-40-0
N-{3-[3-tert-butyl-5-(5-fluoro-2-oxo-1,2-dihydro-pyridin-3-yl)-2-methoxy-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 90 °C / Sealed tube; Microwave Irradiation

2: hydrogen bromide / acetic acid / 65 °C

With hydrogen bromide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; acetic acid;