isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1258001-80-7
Molecular Formula:C₂₃H₂₇FN₈O₄
Molecular Weight:498.517
Hs Code.:

Synonyms:isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Technology Process of isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 11 articles about isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1258001-81-8
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-(trimethylsilyloxy)ethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1258001-80-7
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-(trimethylsilyloxy)ethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 1079396-35-2
isopropyl 4-(2-(tert-butoxycarbonyl)hydrazinyl)piperidine-1-carboxylate

: 1258001-80-7
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / ethanol / 4 h / 20 °C / Inert atmosphere

1.2: 14 h / 20 °C

2.1: sodium acetate / ethanol / 3 h / 85 °C

3.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 - 65 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 25 h / 0 - 20 °C / Reflux

4.2: 0.17 h / 0 - 20 °C

5.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 1 h / 120 °C / Inert atmosphere; microwave reactor

6.1: triphenylphosphine; diethylazodicarboxylate / 1,4-dioxane / 15 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With hydrogenchloride; tert.-butylnitrite; dimethylsulfide borane complex; water; sodium acetate; triphenylphosphine; copper(ll) bromide; zinc; diethylazodicarboxylate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

: 405-04-9
3-fluoro-4-hydroxybenzonitrile

: 1258001-80-7
isopropyl 4-(5-cyano-4-((2-fluoro-4-(2-(2-hydroxyethyl)-2H-tetrazol-5-yl)phenoxy)methyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 0.17 h

1.2: 70 h / 20 °C

2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 18 h / 110 °C

2.2: 20 °C / pH 3

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 20 °C

3.2: 16 h / 70 °C

4.1: formic acid / palladium / ethanol; tetrahydrofuran / 4 h / 20 °C

5.1: triphenylphosphine; diethylazodicarboxylate / 1,4-dioxane / 15 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

With hydrogenchloride; formic acid; sodium azide; sodium hydride; potassium carbonate; ammonium chloride; triphenylphosphine; diethylazodicarboxylate; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;