C₃₄H₃₉N₅O₅

Base Information

• Chemical Name: C₃₄H₃₉N₅O₅
• CAS No.: 868287-37-0
• Molecular Formula: C₃₄H₃₉N₅O₅
• Molecular Weight: 597.714
• Mol file: 868287-37-0.mol

Synonyms:C₃₄H₃₉N₅O₅

Chemical Property of C₃₄H₃₉N₅O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₄H₃₉N₅O₅

There total 5 articles about C₃₄H₃₉N₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H41N5O6 (868286-82-2) → C34H39N5O5 (868287-37-0)

Guidance literature:

With Burgess Reagent; In 1,2-dichloro-ethane; at 100 ℃; for 0.0833333h; Microwave;

Reference yield:

3-bromo-5-(5-((1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl)benzoic acid (1048686-05-0) → C34H39N5O5 (868287-37-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 50 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 120 °C

3: lithium hydroxide; water / tetrahydrofuran / 50 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 5 h / 20 °C

5: Burgess Reagent / 1,2-dichloro-ethane / 0.08 h / 100 °C / Microwave

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; Burgess Reagent; water; sodium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; 1,2-dichloro-ethane;

Reference yield:

tert-butyl [1-(5-{3-bromo-5-[(dipropylamino)carbonyl]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate (868286-60-6) → C34H39N5O5 (868287-37-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran / 50 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 5 h / 20 °C

4: Burgess Reagent / 1,2-dichloro-ethane / 0.08 h / 100 °C / Microwave

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; Burgess Reagent; water; sodium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; 1,2-dichloro-ethane;

upstream raw materials:

C₃₄H₄₁N₅O₆

3-bromo-5-(5-((1R)-1-[(tert-butoxycarbonyl)amino]-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl)benzoic acid

tert-butyl [1-(5-{3-bromo-5-[(dipropylamino)carbonyl]phenyl}-1,3,4-oxadiazol-2-yl)-(1R)-1-methyl-2-phenylethyl]carbamate

methyl-2-{3-[5-((1R)-1-(tert-butoxycarbonylamino)-1-methyl-2-phenylethyl)-1,3,4-oxadiazol-2-yl]-5-[(dipropylamino)carbonyl]phenyl}-3-furoate