Technology Process of 3-(10'-benzyloxytetradec-3',13'-dien-1'-yl)-5,7-dimethoxy-(3H)-isobenzofuran-1-one
There total 14 articles about 3-(10'-benzyloxytetradec-3',13'-dien-1'-yl)-5,7-dimethoxy-(3H)-isobenzofuran-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[7-(benzyloxy)undec-10-en-1-yl]triphenylphosphonium bromide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 0.5h;
5,7-dimethoxy-3-(3'-oxoprop-1'-yl)-(3H)-isobenzofuran-1-one;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
DOI:10.1016/j.tet.2005.08.027
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 99 percent / 3-chloroperoxybenzoic acid; sodium acetate / CH2Cl2 / 19 h / 0 - 20 °C
2.1: 55 percent / copper(I) cyanide / diethyl ether / 10 h / -78 °C
3.1: 81 percent / sodium hydride; tetrabutylammonium iodide / dimethylformamide / 18 h / 20 °C
4.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
5.1: 98 percent / carbon tetrabromide; triphenylphosphine / acetonitrile / 0 - 20 °C
6.1: 80 percent / acetonitrile / 26 h / Heating
7.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
7.2: 72 percent / tetrahydrofuran; hexane / -78 - 20 °C
With
n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; sodium acetate; copper(l) cyanide; tetra-(n-butyl)ammonium iodide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
7.2: Wittig reaction;
DOI:10.1016/j.tet.2005.08.027
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 55 percent / copper(I) cyanide / diethyl ether / 10 h / -78 °C
2.1: 81 percent / sodium hydride; tetrabutylammonium iodide / dimethylformamide / 18 h / 20 °C
3.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
4.1: 98 percent / carbon tetrabromide; triphenylphosphine / acetonitrile / 0 - 20 °C
5.1: 80 percent / acetonitrile / 26 h / Heating
6.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C
6.2: 72 percent / tetrahydrofuran; hexane / -78 - 20 °C
With
n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; copper(l) cyanide; tetra-(n-butyl)ammonium iodide; sodium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; acetonitrile;
6.2: Wittig reaction;
DOI:10.1016/j.tet.2005.08.027
