2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone

Base Information

• Chemical Name: 2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone
• CAS No.: 79222-80-3
• Molecular Formula: C₁₅H₁₇BrN₂O
• Molecular Weight: 321.217
• Mol file: 79222-80-3.mol

Synonyms:2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone

Chemical Property of 2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone

Chemical Property:

Purity/Quality:

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Technology Process of 2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone

There total 1 articles about 2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1,5-dibromo-pentane (111-24-0) + 6-phenylpyridazin-3(2H)-one (2166-31-6) → 2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone (79222-80-3)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In benzene; for 6h; Ambient temperature;

DOI:10.1055/s-1981-29552

Reference yield: 81.0%

potassium cyanide (151-50-8) + 2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone (79222-80-3) → 2-(5-cyanopentyl)-6-phenyl-3(2H)-pyridazinone (79222-74-5)

Guidance literature:

With tetrabutylammomium bromide; In benzene; at 50 - 60 ℃; for 10h;

DOI:10.1021/jm00350a018

Reference yield: 66.0%

2-(2-bromopentyl)-6-phenyl-3(2H)-pyridazinone (79222-80-3) → 2-(2-aminopentyl)-6-phenyl-3(2H)-pyridazinone (82362-85-4)

Guidance literature:

With ammonium hydroxide; In ethanol; at 40 ℃; for 24h;

DOI:10.1021/jm00357a012

upstream raw materials:

1,5-dibromo-pentane

6-phenylpyridazin-3(2H)-one

Downstream raw materials:

2-(5-cyanopentyl)-6-phenyl-3(2H)-pyridazinone

2-(2-aminopentyl)-6-phenyl-3(2H)-pyridazinone

MUL-037

1-Ethyl-3-[5-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-pentyl]-thiourea

Refernces

• 1、 Yamada,Tsukamoto,Shimamura,et al.. "Pyridazinones. IV. Synthesis, antisecretory and antiulcer activities of urea derivatives". . p. 209 - 214. Retrieved 2007/10/02.
• 2、 Yamada, Toshihiro,Ohki, Masahiko. "Phase-Transfer Catalyzed N-Alkylation of 3(2H)-Pyridazinones (3-Oxo-2,3-dihydropyridazines)". . p. 631 - 633. Retrieved 2007/10/02.