Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester

Base Information

• Chemical Name: Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester
• CAS No.: 157117-19-6
• Molecular Formula: C₃₂H₃₉NO₇SSi
• Molecular Weight: 609.816
• Mol file: 157117-19-6.mol

Synonyms:Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester

Chemical Property of Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester

There total 5 articles about Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (1R,2S)-2-benzoylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-((2R,4S,5R)-5-methanesulfonyloxy-2-methyl-[1,3]dioxan-4-yl)-propyl ester (157117-18-5) → Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester (157117-19-6)

Guidance literature:

With triethylamine; In pyridine; toluene; at 110 ℃; for 24h;

DOI:10.1016/S0040-4039(00)75806-0

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester (157117-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; CH₂Cl₂ / 24 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: Et₃N / pyridine; toluene / 24 h / 110 °C

With triethylamine; In pyridine; dichloromethane; toluene;

DOI:10.1016/S0040-4039(00)75806-0

Reference yield:

4,6-O-ethylidene-N-benzoyl-D-glucosamine → Methanesulfonic acid (2R,4S,5R)-4-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-methyl-[1,3]dioxan-5-yl ester (157117-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / NaBH₄ / propan-2-ol; H₂O / 1 h / 0 °C

2: pyridine; CH₂Cl₂ / 24 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 2 h / 0 °C

4: Et₃N / pyridine; toluene / 24 h / 110 °C

With sodium tetrahydroborate; triethylamine; In pyridine; dichloromethane; water; isopropyl alcohol; toluene;

DOI:10.1016/S0040-4039(00)75806-0

upstream raw materials:

Methanesulfonic acid (1R,2S)-2-benzoylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-((2R,4S,5R)-5-methanesulfonyloxy-2-methyl-[1,3]dioxan-4-yl)-propyl ester

tert-butylchlorodiphenylsilane

2-Benzamido-2-deoxy-4,6-O-ethylidene-D-glucitol

Downstream raw materials:

Methanesulfonic acid (1R,2S)-2-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-2-hydroxy-1-hydroxymethyl-ethyl ester

Toluene-4-sulfonic acid (2S,3S)-3-[(4S,5S)-4-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazol-5-yl]-oxiranylmethyl ester

(4S,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2-phenyl-5-((2R,3S)-3-tridecyl-oxiranyl)-4,5-dihydro-oxazole

N-[(1S,2S,3R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2,3-dihydroxy-heptadecyl]-benzamide