N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide

Base Information

• Chemical Name: N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide
• CAS No.: 895569-28-5
• Molecular Formula: C₂₁H₂₀N₂O₄
• Molecular Weight: 364.401
• Mol file: 895569-28-5.mol

Synonyms:N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide

Chemical Property of N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide

There total 4 articles about N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-1H-isochromene-1,3(4H)-dione (4702-29-8) + 3-amino-N-cyclopropyl-4-methylbenzamide (623155-19-1) → N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide (895569-28-5)

Guidance literature:

With acetic acid; In toluene; at 150 ℃; for 1.5h; Microwave irradiation;

Reference yield:

4-methyl-3-nitrobenzoyl chloride (10397-30-5) → N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide (895569-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethame / 16 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

3: acetic acid; toluene / 1.5 h / 150 °C / Irradiation

With hydrogen; triethylamine; palladium 10% on activated carbon; In dichloromethame; ethanol; acetic acid; toluene;

Reference yield:

N-cyclopropyl-4-methyl-3-nitrobenzamide (303133-89-3) → N-cyclopropyl-3-(7-methoxy-1,3-dioxo-3,4-dihydro-1H-isoquinolin-2-yl)-4-methylbenzamide (895569-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

2: acetic acid; toluene / 1.5 h / 150 °C / Irradiation

With hydrogen; palladium 10% on activated carbon; In ethanol; acetic acid; toluene;

upstream raw materials:

7-methoxy-1H-isochromene-1,3(4H)-dione

3-amino-N-cyclopropyl-4-methylbenzamide

N-cyclopropyl-4-methyl-3-nitrobenzamide

2-(carboxymethyl)-5-methoxybenzoic acid

Downstream raw materials:

N-cyclopropyl-3-(7-hydroxy-1-oxo-1H-isoquinolin-2-yl)-4-methylbenzamide

3-(7-hydroxy-1-oxo-1H-isoquinolin-2-yl)-4-methylbenzoic acid

2-(5-amino-2-methylphenyl)-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-1(2H)-one

4-methyl-3-[1-oxo-7-(2-pyrrolidin-1-ylethoxy)isoquinolin-2(1H)-yl]benzoic acid