4-Cyano-2-phenylpyridine

Base Information

• Chemical Name: 4-Cyano-2-phenylpyridine
• CAS No.: 33744-17-1
• Molecular Formula: C₁₂H₈N₂
• Molecular Weight: 180.209
• Hs Code.: 2933399990
• Mol file: 33744-17-1.mol

Synonyms:2-phenylpyridine-4-carbonitrile

Chemical Property of 4-Cyano-2-phenylpyridine

Chemical Property:

• Vapor Pressure: 0.000235mmHg at 25°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Phenylisonicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Cyano-2-phenylpyridine

There total 17 articles about 4-Cyano-2-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-cyano-1-methoxypyridin-1-ium tetrafluoroborate + phenylboronic acid (98-80-6) → 2-phenylpyridine-4-carbonitrile (33744-17-1)

Guidance literature:

With sodium persulfate; silver nitrate; trifluoroacetic acid; In dichloromethane; water; at 25 ℃; for 0.5h; regioselective reaction;

DOI:10.1016/j.tetlet.2018.02.008

Reference yield: 79.0%

2-chloro-4-pyridinenitrile (33252-30-1) + phenylboronic acid (98-80-6) → 2-phenylpyridine-4-carbonitrile (33744-17-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jacs.1c05764

Reference yield: 78.5%

pyridine-4-carbonitrile (100-48-1) + phenylboronic acid (98-80-6) → 2-phenylpyridine-4-carbonitrile (33744-17-1) + 3-phenylpyridine-4-carbonitrile (36146-27-7)

Guidance literature:

With iron sulfide; ammonium persulfate; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 24h; Reagent/catalyst;

upstream raw materials:

2-phenylisonicotinamide

pyridine-4-carbonitrile

dibenzoyl peroxide

2-chloro-6-phenylisonicotinoyl chloride

Downstream raw materials:

2-phenyl-thioisonicotinic acid amide

2-(2-Phenyl-4-pyridyl)-4H-1,3-benzothiazine-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 33744-17-1 4-Cyano-2-phenylpyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send