5-Bromo-m-xylene

Base Information

• Chemical Name: 5-Bromo-m-xylene
• CAS No.: 556-96-7
• Molecular Formula: C8H9Br
• Molecular Weight: 185.063
• Hs Code.: 29036990
• Mol file: 556-96-7.mol

Synonyms:m-Xylene,5-bromo- (6CI,7CI,8CI);1-Bromo-3,5-dimethylbenzene;1-Bromo-3,5-xylene;3,5-Dimethyl-1-bromobenzene;3,5-Dimethylbromobenzene;3,5-Dimethylphenylbromide;5-Bromo-1,3-xylene;

Chemical Property of 5-Bromo-m-xylene

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.333mmHg at 25°C
• Melting Point: -20.49°C (estimate)
• Refractive Index: n20/D 1.549(lit.)
• Boiling Point: 206.9 °C at 760 mmHg
• Flash Point: 87.2 °C
• PSA: 0.00000
• Density: 1.339 g/cm³
• LogP: 3.06590
• Storage Temp.: Store below +30°C.
• Solubility.: Miscible with tetrahydrofuran.

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-m-xylene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-m-xylene has been used in the synthesis of substituted 2,2′-bis(diphenylphosphanylmethyl)-1,1′-binaphthyl derivatives. 5-Bromo-m-xylene is used in the preparation of substituted 2,2'-bis(diphenylphosphanylmethyl)-1,1'-binaphthyl derivatives. It is also used to prepare o-tolyl-3,5-xylyl ether by reacting with o-cresol. Further, it is an organic building block used in the synthesis of various chemicals as well as in the preparation of tri-o-tolylphosphine. 1-Bromo-3,5-dimethylbenzene has been used in the synthesis of substituted 2,2′-bis(diphenylphosphanylmethyl)-1,1′-binaphthyl derivatives.

Technology Process of 5-Bromo-m-xylene

There total 17 articles about 5-Bromo-m-xylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,5-dimethylaminoaniline (108-69-0) → 5-bromo-1,3-xylene (556-96-7)

Guidance literature:

With trimethylsilyl bromide; N-benzyl-N,N,N-triethylammonium chloride; sodium nitrite; In tetrachloromethane; 1.) 0 deg C, 1.5 h, 2.) r.t., 12 h;

DOI:10.1016/S0040-4039(00)79842-X

Reference yield: 85.0%

m-xylene (108-38-3,104809-90-7) → 5-bromo-1,3-xylene (556-96-7)

Guidance literature:

With copper(ll) bromide; aluminum oxide; In tetrachloromethane; at 80 ℃; for 2h;

Reference yield: 71.0%

3,5-dimethylphenyl boronic acid (172975-69-8) → 5-bromo-1,3-xylene (556-96-7)

Guidance literature:

With 1,10-Phenanthroline; oxygen; potassium bromide; copper(ll) bromide; In N,N-dimethyl-formamide; at 130 ℃; for 20h;

DOI:10.1016/j.tetlet.2011.02.075

upstream raw materials:

2-bromo-4,6-dimethylaniline

3,5-dimethylaminoaniline

2,4-Xylidine

1-bromo-2,4-dimethylbenzene

Downstream raw materials:

6-bromo-2,4-dimethyl-1,3,5-trinitrobenzene

1-(3,5-Dimethylphenyl)-1H-indole-2,3-dione

1,2-bis(3,5-dimethylphenyl)ethane-1,2-dione

2-(3,5-dimethylphenyl)naphthalene

Refernces

• 1、 -. "Catalyst". . . Retrieved 2021/03/16.
• 2、 -. "CATALYSTS". . . Retrieved 2018/06/06.