C₄₈H₅₃F₂N₆O₉P

Base Information

• Chemical Name: C₄₈H₅₃F₂N₆O₉P
• CAS No.: 1613589-84-6
• Molecular Formula: C₄₈H₅₃F₂N₆O₉P
• Molecular Weight: 926.954
• Mol file: 1613589-84-6.mol

Synonyms:C₄₈H₅₃F₂N₆O₉P

Chemical Property of C₄₈H₅₃F₂N₆O₉P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₅₃F₂N₆O₉P

There total 17 articles about C₄₈H₅₃F₂N₆O₉P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-phenyl-N-(S)-1-(cyclohexoxycarbonyl)ethylphosphoramidic chloride (220592-67-6) + C53H49F2N5O6 (1613589-82-4) → C68H69F2N6O10P (1613589-83-5) + C48H53F2N6O9P (1613589-84-6)

Guidance literature:

With 1-methyl-1H-imidazole; In acetonitrile; at 0 - 5 ℃; for 4h;

Reference yield:

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate) (1199809-24-9) → C68H69F2N6O10P (1613589-83-5) + C48H53F2N6O9P (1613589-84-6)

Guidance literature:

Multi-step reaction with 10 steps

1.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C

1.2: 50 °C

2.1: silver nitrate / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium ethanolate / 1 h / 0 - 20 °C

4.1: triphenylphosphine; pyridine; iodine / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Reflux

6.1: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 0 - 20 °C

7.1: silver nitrate / dichloromethane / 0 - 20 °C

8.1: 15-crown-5 / N,N-dimethyl-formamide / 72 h / 95 °C

9.1: ammonia / methanol / 18 h / 20 °C

10.1: 1-methyl-1H-imidazole / acetonitrile / 4 h / 0 - 5 °C

With pyridine; 1-methyl-1H-imidazole; N-iodo-succinimide; 15-crown-5; potassium tert-butylate; ammonia; iodine; sodium ethanolate; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate (1199809-26-1) → C68H69F2N6O10P (1613589-83-5) + C48H53F2N6O9P (1613589-84-6)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium ethanolate / 1 h / 0 - 20 °C

2: triphenylphosphine; pyridine; iodine / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Reflux

4: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 0 - 20 °C

5: silver nitrate / dichloromethane / 0 - 20 °C

6: 15-crown-5 / N,N-dimethyl-formamide / 72 h / 95 °C

7: ammonia / methanol / 18 h / 20 °C

8: 1-methyl-1H-imidazole / acetonitrile / 4 h / 0 - 5 °C

With pyridine; 1-methyl-1H-imidazole; N-iodo-succinimide; 15-crown-5; ammonia; iodine; sodium ethanolate; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

O-phenyl-N-(S)-1-(cyclohexoxycarbonyl)ethylphosphoramidic chloride

C₅₃H₄₉F₂N₅O₆

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate)

Refernces