4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

Base Information

Chemical Name:4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol
CAS No.:719272-76-1
Molecular Formula:C₂₄H₂₄F₃N₃O
Molecular Weight:427.469
Hs Code.:

Synonyms:4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

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Chemical Property of 4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

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Technology Process of 4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

There total 5 articles about 4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[4-(benzyloxy)-2-(trifluoromethyl)phenyl]-4-methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazole

: 719272-76-1
4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 3h; under 760.051 Torr;

Reference yield:

: 953-69-5
4-phenylbicyclo<2.2.2>octane-1-carboxylic acid

: 719272-76-1
4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine / dichloromethane / 4 h / 20 °C

4: methylamine / methanol / 150 °C

5: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

With oxalyl dichloride; hydrogen; 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; methylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 719274-60-9
2-[4-(benzyloxy)-2-(trifluoromethyl)phenyl]-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-1,3,4-oxadiazole

: 719272-76-1
4-[4-Methyl-5-(4-phenylbicyclo[2.2.2]oct-1-yl)-4H-1,2,4-triazol-3-yl]-3-(trifluoromethyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: methylamine / methanol / 150 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr

With hydrogen; methylamine; palladium 10% on activated carbon; In methanol; ethyl acetate;