4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol

Base Information

• Chemical Name: 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol
• CAS No.: 161990-36-9
• Molecular Formula: C₃₂H₄₄O₄Si
• Molecular Weight: 520.784

Synonyms:4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol

Chemical Property of 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol

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Technology Process of 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol

There total 4 articles about 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

propargyl bromide (106-96-7) + 1-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-4-(4-methoxy-benzyloxy)-4-methyl-pent-2-yn-1-one (161990-33-6) → 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol (161990-36-9)

Guidance literature:

With zinc; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/0040-4039(94)02330-E

Reference yield:

2-benzofuran-1(3H)-one (87-41-2) → 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol (161990-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / n-BuLi / tetrahydrofuran / -78 °C

2: 97 percent / imidazole / CH₂Cl₂ / 25 °C

3: 92 percent / Zn / tetrahydrofuran / 25 °C

With 1H-imidazole; n-butyllithium; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(94)02330-E

Reference yield:

1-(1,1-Dimethyl-prop-2-ynyloxymethyl)-4-methoxy-benzene → 4-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-7-(4-methoxy-benzyloxy)-7-methyl-octa-1,5-diyn-4-ol (161990-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / n-BuLi / tetrahydrofuran / -78 °C

2: 97 percent / imidazole / CH₂Cl₂ / 25 °C

3: 92 percent / Zn / tetrahydrofuran / 25 °C

With 1H-imidazole; n-butyllithium; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(94)02330-E

upstream raw materials:

propargyl bromide

1-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-phenyl}-4-(4-methoxy-benzyloxy)-4-methyl-pent-2-yn-1-one

2-benzofuran-1(3H)-one

1-(2-Hydroxymethyl-phenyl)-4-(4-methoxy-benzyloxy)-4-methyl-pent-2-yn-1-one

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