(S)-3-Hydroxy-gamma-butyrolactone

Base Information Edit

Chemical Name:(S)-3-Hydroxy-gamma-butyrolactone
CAS No.:7331-52-4
Molecular Formula:C₄H₆O₃
Molecular Weight:102.09
Hs Code.:29322090
European Community (EC) Number:434-990-4,623-293-2
UNII:2LIE7314JH
DSSTox Substance ID:DTXSID60428483
Nikkaji Number:J517.046J
Wikidata:Q27254893
Metabolomics Workbench ID:169371
Mol file:7331-52-4.mol

Synonyms:7331-52-4;(S)-3-Hydroxy-gamma-butyrolactone;(S)-4-Hydroxydihydrofuran-2(3H)-one;(4S)-4-hydroxyoxolan-2-one;3-Hydroxybutyrolactone, (3S)-;(S)-beta-Hydroxy-gamma-butyrolactone;2(3H)-Furanone, dihydro-4-hydroxy-, (4S)-;UNII-2LIE7314JH;2LIE7314JH;EC 434-990-4;MFCD00211247;(S)-4-Hydroxytetrahydrofuran-2-one;(4S)-4-Hydroxydihydrofuran-2(3H)-one;(S)-(-)-3-Hydroxy-gama-butyro lactone;(S)-4,5-Dihydro-4-hydroxy-2(3H)-furanone;(S)-3-hydroxybutyrolactone;(3s)-3-hydroxybutyrolactone;SCHEMBL574767;(S)-4-Hydroxyoxolane-2-one;(4S)-4-hydroxy-2-oxolanone;(4S)-4-oxidanyloxolan-2-one;(S)-3-hydroxy-g-butyrolactone;AMY4221;DTXSID60428483;FUDDLSHBRSNCBV-VKHMYHEASA-N;(S)-4-Hydroxy-dihydro-furan-2-one;GEO-03952;AKOS016842346;3-HYDROXYBUTYROLACTONE, (-)-;CS-W013702;(|S|)-beta-Hydroxy-gamma-butyrolactone;(4S)-4-Hydroxydihydro-2(3H)-furanone;(S)-(-)-?-Hydroxy-gamma-butyrolactone;AC-13891;(S)- beta -Hydroxy- gamma -butyrolactone;(S)-beta-Hydroxy-gamma-butyrolactone, 96%;(S)-3-HYDROXY-.GAMMA.-BUTYROLACTONE;H0939;EN300-102216;H11711;(S)-.BETA.-HYDROXY-.GAMMA.-BUTYROLACTONE;A837785;Q27254893;(S)-(-)-.BETA.-HYDROXY-.GAMMA.-BUTYROLACTONE;BUTYRIC ACID, 3,4-DIHYDROXY-, .GAMMA.-LACTONE, D-GLYCERO-

Suppliers and Price of (S)-3-Hydroxy-gamma-butyrolactone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-3-Hydroxy-γ-butyrolactone
2.5g
$ 90.00

TRC
(S)-3-Hydroxy-γ-butyrolactone
500mg
$ 60.00

TCI Chemical
(S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC)
1g
$ 53.00

TCI Chemical
(S)-3-Hydroxy-gamma-butyrolactone >95.0%(GC)
5g
$ 149.00

Sigma-Aldrich
(S)-β-Hydroxy-γ-butyrolactone 96%
1g
$ 74.90

Matrix Scientific
(S)-4-Hydroxydihydrofuran-2(3H)-one 85+%
25g
$ 512.00

Matrix Scientific
(S)-4-Hydroxydihydrofuran-2(3H)-one 85+%
5g
$ 153.00

Matrix Scientific
(S)-4-Hydroxydihydrofuran-2(3H)-one 85+%
1g
$ 51.00

J&W Pharmlab
S-beta-Hydroxy-gamma-butyrolactone 98%
25g
$ 51.00

Crysdot
(S)-4-Hydroxydihydrofuran-2(3H)-one 95%
25g
$ 245.00

Total 153 raw suppliers

Chemical Property of (S)-3-Hydroxy-gamma-butyrolactone Edit

Chemical Property:

Appearance/Colour:Colorless to light yellow liquid
Vapor Pressure:5.42E-05mmHg at 25°C
Melting Point:1.24ºC
Refractive Index:n20/D 1.464(lit.)
Boiling Point:310.3 °C at 760 mmHg
PKA:12.87±0.20(Predicted)
Flash Point:157 °C
PSA：46.53000
Density:1.393 g/cm³
LogP:-0.70580
Storage Temp.:2-8°C
Water Solubility.:Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum.
XLogP3:-0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:102.031694049
Heavy Atom Count:7
Complexity:88.9

Purity/Quality:

98% ^*data from raw suppliers

(S)-3-Hydroxy-γ-butyrolactone ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(COC1=O)O
Isomeric SMILES:C1[C@@H](COC1=O)O
Description (S)-3-Hydroxy-gamma-butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S-oxiracetam (S-ORC). It can be deoxidized to (S)-(+)-3-Hydroxytetrahydrofuran which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer.
Uses (S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor.

Technology Process of (S)-3-Hydroxy-gamma-butyrolactone

There total 71 articles about (S)-3-Hydroxy-gamma-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%