1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate
• CAS No.: 1620488-64-3
• Molecular Formula: C₂₂H₂₂FN₅O₄
• Molecular Weight: 439.446

Synonyms:1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate

Chemical Property of 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate

There total 3 articles about 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C12H10ClFN2O2 (1620488-80-3) + 4-nitro-aniline (100-01-6,104810-17-5) → 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate (1620488-64-3)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2014.07.001

Reference yield:

1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol (24155-46-2) → 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate (1620488-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 12 h / 20 °C

2: triethylamine / acetonitrile / 12 h / 20 °C

With triethylamine; In acetonitrile;

DOI:10.1016/j.ejmech.2014.07.001

Reference yield:

1-(4-Nitrophenyl)piperazine (6269-89-2) + C12H10ClFN2O2 (1620488-80-3) → 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(4-nitrophenyl)piperazine-1-carboxylate (1620488-64-3)

Guidance literature:

With triethylamine; at 20 ℃;

DOI:10.1016/j.ejmech.2016.02.028

upstream raw materials:

1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

C₁₂H₁₀ClFN₂O₂

4-nitro-aniline

1-(4-Nitrophenyl)piperazine

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