(E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

Base Information

Chemical Name:(E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester
CAS No.:182011-35-4
Molecular Formula:C₁₇H₂₅NO₂
Molecular Weight:275.391
Hs Code.:

Synonyms:(E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

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Chemical Property of (E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

Chemical Property:

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Technology Process of (E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

There total 4 articles about (E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-6-(6-tert-Butoxycarbonylamino-2,3,4-trimethyl-phenyl)-4-methyl-hex-4-enoic acid methyl ester

: 182011-35-4
(E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 50 ℃; for 12h; Yield given;
DOI:10.1021/jm9603633

Reference yield:

: 2217-45-0
2,3,4,5-tetramethylaniline

: 182011-35-4
(E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / tetrahydrofuran / 24 h

2: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to -20 deg C, 2.) THF, pentane, -78 deg C, 5 min

3: pivalic acid / Heating

4: p-TsOH*H₂O / methanol / 12 h / 50 °C

With tert.-butyl lithium; toluene-4-sulfonic acid; Trimethylacetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm9603633

Reference yield:

: 182011-33-2
N-(tert-butoxycarbonyl)-2,3,4,5-tetramethylaniline

: 182011-35-4
(E)-6-(6-amino-2,3,4-trimethylphenyl)-4-methyl-4-hexenoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to -20 deg C, 2.) THF, pentane, -78 deg C, 5 min

2: pivalic acid / Heating

3: p-TsOH*H₂O / methanol / 12 h / 50 °C

With tert.-butyl lithium; toluene-4-sulfonic acid; Trimethylacetic acid; In methanol;
DOI:10.1021/jm9603633