Technology Process of methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate
There total 10 articles about methyl 5-iodo-2-[(5S)-5-(ethenyl)-2-oxo-1-pyrrolidinyl]benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 5-iodo-2-[(5S)-5-(hydroxyethyl)-2-oxo-1-pyrrolidinyl]benzoate;
With
ortho-nitrophenyl selenocyanate; tributylphosphine;
In
tetrahydrofuran;
With
dihydrogen peroxide;
In
tetrahydrofuran;
DOI:10.1016/j.tetlet.2007.02.008
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 75 percent / Et3N / CH2Cl2
2.1: 95 percent / dimethylsulfoxide
3.1: 55 percent / H2SO4; H2O
4.1: 90 percent / NaBH4 / methanol
5.1: 95 percent / imidazole / dimethylformamide
6.1: 61 percent / xantphos; Cs2CO3 / Pd2dba3 / dioxane
7.1: 90 percent / H2 / Pd/C / ethanol
8.1: n-C5H11ONO; CH2I2
9.1: TBAF / tetrahydrofuran
10.1: o-NO2C6H4SeCN; PBu3 / tetrahydrofuran
10.2: 85 percent / H2O2 / tetrahydrofuran
With
1H-imidazole; sodium tetrahydroborate; ortho-nitrophenyl selenocyanate; diiodomethane; n-Amyl nitrite; tributylphosphine; sulfuric acid; tetrabutyl ammonium fluoride; water; hydrogen; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
tris-(dibenzylideneacetone)dipalladium(0); palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2007.02.008
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 90 percent / H2 / Pd/C / ethanol
2.1: n-C5H11ONO; CH2I2
3.1: TBAF / tetrahydrofuran
4.1: o-NO2C6H4SeCN; PBu3 / tetrahydrofuran
4.2: 85 percent / H2O2 / tetrahydrofuran
With
ortho-nitrophenyl selenocyanate; diiodomethane; n-Amyl nitrite; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
DOI:10.1016/j.tetlet.2007.02.008
![methyl 5-iodo-2-[(5S)-5-(hydroxyethyl)-2-oxo-1-pyrrolidinyl]benzoate](/Databaselist/images/loading.webp)
